Coffee vs Alzheimer’s disease

Coffee vs Alzheimer’s disease?

  • Alzheimer’s disease (AD) is the most common type of dementia affecting more than 55 million people worldwide.
  • A new Australian study showed that:
    • Habitual coffee drinking is positively associated with the cognitive areas of executive function, attention, and the PACC score.
    • Drinking higher amounts of coffee is associated with slower cognitive decline in these areas over the course of the study (Reduce by up to 8% after 18 months)
    • Higher baseline coffee consumption is also linked to a slower accumulation of amyloid protein over the 126 months (up to a 5% decrease in cerebral beta-amyloid accumulation after 18 months)
  • Compounds other than caffeine:
    • Crude caffeine: e by-product of de-caffeinating coffee appears to be effective in partially preventing memory impairment in mice,
    • Cafestol, kahweol, and Eicosanoyl-5-hydroxytryptamide also seem to affect cognitive impairment in various animal studies.
  • Researchers say that it’s necessary to confirm these findings through more long-term observational and intervention studies.

Do you want to read more about this topic?

  1. Samantha L. Gardener, Stephanie R. Rainey-Smith, Victor L. Villemagne, Jurgen Fripp, Vincent Doré, Pierrick Bourgeat, Kevin Taddei, Christopher Fowler, Colin L. Masters, Paul Maruff, Christopher C. Rowe, David Ames, Ralph N. Martins. Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study. Frontiers in Aging Neuroscience, 2021; 13 DOI: 10.3389/fnagi.2021.744872

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