Non coding DNA parts or Junk DNA appears to be important in brain development & evolution
- Lund University researchers compared the brain cells from humans and chimpanzees grown from the stem cells.
- Chimpanzee is our closest living relative from the evolutionary point of view however researchers found that chimpanzees & humans use a part of their DNA in different ways, which plays a role in brain development,
- The Non coding DNA or junk DNA is a repetitive DNA string that covers >98% of the entire DNA has long been thought to have no functions however the “protein-producing genes” coding DNA regions that count for <2%.
- The new findings that the bases of the human brain’s evolution are genetic mechanisms that appear to be hidden in the overlooked 98 % of the DNA called “Non coding DNA or Junk DNA”
- A surprising finding with the shift of paradigm!
Do you want to read more about this topic?
- Pia A. Johansson, Per Ludvik Brattås, Christopher H. Douse, PingHsun Hsieh, Anita Adami, Julien Pontis, Daniela Grassi, Raquel Garza, Edoardo Sozzi, Rodrigo Cataldo, Marie E. Jönsson, Diahann A.M. Atacho, Karolina Pircs, Feride Eren, Yogita Sharma, Jenny Johansson, Alessandro Fiorenzano, Malin Parmar, Malin Fex, Didier Trono, Evan E. Eichler, Johan Jakobsson. A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development. Cell Stem Cell, 2021; DOI: 10.1016/j.stem.2021.09.008