RBC microRNAs-210 levels: a potential diagnostic marker to predict vascular complications in type 2 diabetes
- MicroRNA are naturally occurring molecules to regulate vascular activity & other cellular functions.
- The study by researchers at Karolinska Institutet shows that the microRNA-210 levels in RBCs were markedly in 36 patients with type 2 diabetes (DM 2) compared with the RBCs of 32 healthy subjects.
- Deceased microRNA-210 levels in RBCs cause alterations in specific vascular protein levels leads to endothelial dysfunction then vascular injury & restoration of microRNA-210 levels in RBCs prevented the development of vascular injury through specific molecular changes laboratory models.
- In the future, RBC microRNAs-210 levels shall become a diagnostic marker to predict diabetic vascular complications & replenish RBC microRNA shall become a therapeutic target to improve the endothelial dysfunction/injury in diabetic subjects.
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- Zhichao Zhou, Aida Collado, Changyan Sun, Yahor Tratsiakovich, Ali Mahdi, Hanna Winter, Ekaterina Chernogubova, Till Seime, Sampath Narayanan, Tong Jiao, Hong Jin, Michael Alvarsson, Xiaowei Zheng, Jiangning Yang, Ulf Hedin, Sergiu-Bogdan Catrina, Lars Maegdefessel, John Pernow. Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes. Diabetes, 2021; db210093 DOI: 10.2337/db21-0093