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  • Researchers from the UC Davis School of Medicine studied 32 pregnant participants for 16 days, they were prescribed probiotic capsule X 2 times a day for 6 days then the cycle was repeated.
  • Observations: 17 observations of their symptoms per day were recorded (a total of 535 observations)
  • Results:
    • Nausea hours were reduced by 16%
    • The number of times they vomited was reduced by 33%
    • Significantly improved symptoms related to the quality of life (fatigue. poor appetite & constipation)
  • Fecal specimens of the participants were analyzed before and during the study to identify the type and number of microbes and the different by-products of digestion.
  • Results:
    • Decreased amount of bacteria with bile salt hydrolase which generates bile acid to absorb nutrients was associated with pregnancy-induced vomiting.
    • The increased amount of gut microbes Akkermansia and A.muciniphila were associated with more vomiting.
    • Probiotics increased the amount of the bile salt hydrolase-producing bacteria & reduced the amount of Akkermansia and A.muciniphila (might be reliable biomarkers that can predict vomiting in pregnancy)
    • Probiotics also increased vitamin E which was associated with low vomiting scores.
  • Insight into the new mechanism of Pregnancy-induced nausea and vomiting
    • Pregnancy –>  hormonal changes –> change the gut microbiome –> affects the GIT & neurological functions –> nausea, vomiting, and constipation.

Do you want to read more about this topic?

  1. Albert T. Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Hu, Yu-Jui Yvonne Wan. Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy. Nutrients, 2021; 13 (11): 3931 DOI: 10.3390/nu13113931
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